One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies

Bioorg Chem. 2016 Apr:65:38-47. doi: 10.1016/j.bioorg.2016.01.004. Epub 2016 Jan 21.

Abstract

In the present study, one-pot synthesis of 1H-tetrazole linked 1,2,5,6-tetrahydronicotinonitriles under solvent-free conditions have been carried out in the presence of tetra-n-butyl ammonium fluoride trihydrated (TBAF) as catalyst and solvent. Computational studies have been conducted to elaborate two plausible mechanistic pathways of this one-pot reaction. Moreover, the synthesized compounds were screened for cholinesterases (acetylcholinesterase and butyrylcholinesterase) inhibition which are consider to be major malefactors of Alzheimer's disease (AD) to find lead compounds for further research in AD therapy.

Keywords: 1,2,5,6-Tetrahydronicotinonitrile; Acetylcholinesterase (AChE); Butyrylcholinesterase (BChE); Click chemistry; Density Functional Theory (DFT); Ionic liquids; Tetrazole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / metabolism
  • Butyrylcholinesterase / metabolism*
  • Cholinergic Agents / chemical synthesis*
  • Cholinergic Agents / chemistry
  • Cholinergic Agents / pharmacology*
  • Cholinesterase Inhibitors / chemical synthesis*
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Molecular Structure
  • Nitriles / chemical synthesis*
  • Nitriles / chemistry
  • Nitriles / pharmacology*
  • Quantum Theory
  • Structure-Activity Relationship

Substances

  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Nitriles
  • Acetylcholinesterase
  • Butyrylcholinesterase